홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → 8-amino-9-fluoro-3-methyl-10-[(3-cyclopropylaminomethyl)-1-pyrrolidinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

HRID 2372090
노트
인쇄 미리보기

반응식

HRID 2372090 반응식
[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]([C:17]([OH:19])=[O:18])=[CH:12][N:7]3[CH:8]([CH3:11])[CH2:9][O:10][C:5]([C:6]=23)=[C:4](F)[C:3]=1[F:21].[CH:22]1([NH:25][CH2:26][CH:27]2[CH2:31][CH2:30]NC2)[CH2:24][CH2:23]1.[CH2:32]([N:34](CC)CC)C>CN(C)C=O>[NH2:1][C:2]1[C:15]2[C:14](=[O:16])[C:13]([C:17]([OH:19])=[O:18])=[CH:12][N:7]3[CH:8]([CH3:11])[CH2:9][O:10][C:5]([C:6]=23)=[C:4]([N:34]2[CH2:32][CH2:30][CH2:31][CH:27]2[CH2:26][NH:25][CH:22]2[CH2:23][CH2:24]2)[C:3]=1[F:21]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 13491801N-(Pyrrolidin-3-ylmethyl)cyclopropanamineHCID 143913498-amino-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de][1,4]benzoxazine-6-carboxylic acid

생성물 1

HCID 679063138-amino-9-fluoro-3-methyl-10-[(3-cyclopropylaminomethyl)-1-pyrrolidinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2.96 g (10 mmole) of 8-amino-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido [1,2,3-de][1,4]benzoxazine-6-carboxylic acid, 2.1 g (15 mmole) of N-cyclopropyl-3-pyrrolidinemethanamine, 3.03 g (30 mmole) of triethylamine and 100 ml of N,N-dimethylformamide is heated at 100° C. for four hours. The solvent is removed in vacuo and the residue triturated with water. The aqueous suspension is adjusted to pH 7.2 with 1.0M hydrochloric acid. The solid is removed by filtration, washed with water, and dried in vacuo to give 8-amino-9-fluoro-3-methyl-10-[(3-cyclopropylaminomethyl)-1-pyrrolidinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid.

후처리

  1. customThe solvent is removed in vacuo
  2. customthe residue triturated with water
  3. customThe solid is removed by filtration
  4. washwashed with water
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-4880d2e8243b403fb57d6c592c02a6f9
출처 데이터셋
uspto-grants-1992_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05097032

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트