Sodium Carbonate → HCID 19903224, 화합물
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O.[NH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][C:10]2=[O:14])[CH2:4][CH2:3]1.[CH2:15]([O:22][C:23]1[C:24](Cl)=[N:25][C:26]([C:29]([F:32])([F:31])[F:30])=[N:27][CH:28]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C>[C:16]1([CH2:15][O:22][C:23]2[C:24]([N:2]3[CH2:3][CH2:4][CH:5]([CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][C:10]4=[O:14])[CH2:6][CH2:7]3)=[N:25][C:26]([C:29]([F:31])([F:32])[F:30])=[N:27][CH:28]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1참가 물질
5
실험 절차
A mixture of 1-[(4-piperidinyl)methyl]-2-pyrrolidinone hydrate (XXV 0.63 g, 3.46 mmol), compound XXIV (1.0 g, 3.46 mmol), and sodium carbonate (0.8 g, 6.92 mmol) in acetonitrile (20 mL) was refluxed for 18 hr. The mixture was cooled, filtered, and concentrated in vacuo. The residue was chromatographed on silica gel using ethyl acetate as the eluent to give the desired product (1.2 g, 79.8%, mp: 155°-157°).