Thionyl Chloride → HCID 14946077, 화합물

HRID 237235

반응식

HRID 237235 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:13])[C:10]([Cl:16])=[O:11])=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 257576p-Methoxyphenylpropionic acid

생성물 1

HCID 14946077HCID 14946077, 화합물

실험 절차

Under an argon atmosphere, 2-(4-methoxyphenyl)propanoic acid (synthesized by the process of I. Shiina, et al., Eur. J. Org. Chem., 5887-5890 (2008)) (1.20 g, 6.66 mmol) was dissolved in thionyl chloride (6.00 mL, 82.6 mmol) and the solution was heated to reflux for 27 hours. After cooling to room temperature, the mixture was concentrated under reduced pressure to give the crude product of 2-(4-methoxyphenyl)propanoyl chloride (16) as a colorless oil. The product was used in the following reaction without further purification.

후처리

  1. temperaturethe solution was heated
  2. temperatureto reflux for 27 hours
  3. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-aaa3d34f55d8495691df1b37dd6c408c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642281B2

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