Aluminium lithium hydride → 1-(1-Benzylpyrrolidin-3-yl)ethan-1-amine

HRID 2372355노트

반응식

HRID 2372355 반응식
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[N:15]O)[CH3:14])[CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:15][CH:13]([CH:11]1[CH2:10][CH2:9][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:12]1)[CH3:14]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 85126173HCID 85126173, 화합물

생성물 1

HCID 190005451-(1-Benzylpyrrolidin-3-yl)ethan-1-amine수율 102.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

30 ml of anhydrous tetrahydrofuran (THF) was added to 650 mg of 1-benzyl-4-(1-hydroxyiminoethyl)-2-pyrrolidone and 500 mg of lithium aluminum hydride and the obtained mixture was refluxed for 20 h. After the decomposition of lithium aluminum hydride, the precipitate was filtered and washed thoroughly with THF. The wash solution was added to the filtrate. The solvent was distilled off under reduced pressure to obtain 587 mg of the desired compound in the form of a light yellow oil.

후처리

  1. temperaturethe obtained mixture was refluxed for 20 h
  2. filtrationAfter the decomposition of lithium aluminum hydride, the precipitate was filtered
  3. washwashed thoroughly with THF
  4. additionThe wash solution was added to the filtrate
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-f3c0550f610847ffaa4b4803b3204c42
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05098912

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