Sodium Acetate → HCID 85114049, 화합물

HRID 2372376노트

반응식

HRID 2372376 반응식
[CH3:1][CH:2]1[CH2:6][NH:5][C:4](=[S:7])[CH:3]1[C:8]([O:10][CH:11]([CH3:13])[CH3:12])=[O:9].C([O-])(=O)C.[Na+].[CH2:19]([O:21][C:22](=[O:28])[CH2:23][C:24]([CH2:26]Br)=O)[CH3:20]>C(O)C>[CH:11]([O:10][C:8]([C:3]1[CH:2]([CH3:1])[CH2:6][N:5]2[C:24](=[CH:23][C:22]([O:21][CH2:19][CH3:20])=[O:28])[CH2:26][S:7][C:4]=12)=[O:9])([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 575284Ethyl 4-bromo-3-oxobutanoateHCID 10465433Isopropyl 4-Methyl-2-thioxopyrrolidine-3-carboxylate

생성물 1

HCID 85114049HCID 85114049, 화합물수율 43.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4.9 g of isopropyl 4-methyl-2-thioxopyrrolidine-3-carboxylate was dissolved in 50 ml of ethanol and 3.0 g of anhydrous sodium acetate and 7.7 g of 4-bromoacetoacetic acid ethyl ester were added thereto. The obtained mixture was stirred at room temperature for 3.5 hours. The crystals thus precipitated were collected by filtration, washed with water and dried. After recrystallization from a mixture of chloroform and ethanol, 3.3 g of the title compound was obtained.

후처리

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customdried
  5. customAfter recrystallization
  6. additionfrom a mixture of chloroform and ethanol

출처 및 근거

ORD 기록
ord-4c9c4bb3448c45f98ce1ec299dad1ffc
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05098919

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