Cinnamyl bromide → 4-[3-((E)-cinnamyloxy)-5-fluorophenyl]-4-ethyl-2,2-dimethyl-1,3-dioxolane

HRID 2372500

반응식

[CH2:1](Br)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:11]([C:13]1([C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[C:22]([OH:27])[CH:21]=2)[CH2:17][O:16][C:15]([CH3:19])([CH3:18])[O:14]1)[CH3:12]>>[CH2:1]([O:27][C:22]1[CH:21]=[C:20]([C:13]2([CH2:11][CH3:12])[CH2:17][O:16][C:15]([CH3:18])([CH3:19])[O:14]2)[CH:25]=[C:24]([F:26])[CH:23]=1)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 5357478Cinnamyl bromide

HCID 190886994-Ethyl-4-(5-fluoro-3-hydroxyphenyl)-2,2-dimethyl-1,3-dioxolane

생성물 1

HCID 197566094-[3-((E)-cinnamyloxy)-5-fluorophenyl]-4-ethyl-2,2-dimethyl-1,3-dioxolane수율 2%

실험 절차

Using the procedure described in Example 6, (E)-cinnamyl bromide was reacted with 4-ethyl-4-(5-fluoro-3-hydroxyphenyl)-2,2-dimethyl-1,3-dioxolane to give 4-[3-((E)-cinnamyloxy)-5-fluorophenyl]-4-ethyl-2,2-dimethyl-1,3-dioxolane in 2% yield, as an oil.

출처 및 근거

ORD 기록: ord-f84fd097ddd948408e3211658c764c83
출처 데이터셋: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05098932

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