Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Methanone, (2,4-difluorophenyl)-4-piperidinyl-, oxime, hydrochloride (1:1) | HCID 57357481 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole | HCID 849421 | — |
반응 단계
1 g of the compound obtained in stage E is mixed with 2.3 g of potassium hydroxide and 5 ml of water. The reaction medium is heated to reflux for 4 hours. 20 ml of water are then added and the mixture is extracted 4 times with 50 ml of toluene. The organic phase is dried to obtain, after evaporation of the solvent, 6-fluoro-3-piperid-4-yl-1,2-benzisoxazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05100902 |
| 출처 데이터셋 | uspto-grants-1992_03 |
| ORD ID | ord-6d3dc7e2398d49acb46cbdf5294cb80e |
| 출처 메모 | uspto-grants-1992_03 |