1-Propanol → 5-(4-(benzyloxy)phenyl)-3-(2-cyanoethyl)-1,3,4-oxadiazol-2(3H)-one

HRID 2372811노트

반응식

HRID 2372811 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19](#[N:22])[CH:20]=[CH2:21].[CH2:23]([OH:26])CC>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]2[O:14][C:23](=[O:26])[N:16]([CH2:21][CH2:20][C:19]#[N:22])[N:15]=2)=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 10311-PropanolHCID 7855Acrylonitrile2회HCID 15264864-(Benzyloxy)benzohydrazide

생성물 1

HCID 30358125-(4-(benzyloxy)phenyl)-3-(2-cyanoethyl)-1,3,4-oxadiazol-2(3H)-one수율 88%

실험 절차

To a solution of 100 mmoles of (4-benzyloxy benzoyl) hydrazine in 200 ml of 1-propanol, 100 mmoles of acrylonitrile are added and the mixture is heated for 24 hours at reflux. Then 50 mmoles of acrylonitrile are added and the heating is continued at reflux for 24 hours. After cooling, the product is filtered and crystallized in a water-ethanol mixture and 26 g (yield: 88%) of the expected product were obtained.

후처리

  1. temperaturethe mixture is heated for 24 hours
  2. temperatureat reflux
  3. temperatureat reflux for 24 hours
  4. temperatureAfter cooling
  5. filtrationthe product is filtered
  6. customcrystallized in a water-ethanol mixture

출처 및 근거

ORD 기록
ord-8f0ceb9136ad43e1a08d0502b1d140ba
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05100910

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