3-hydroxy-4-nitro-3H-isobenzofuran-1-one → 4-Amino-3-hydroxyphthalide

HRID 2372820노트

반응식

HRID 2372820 반응식
[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[N+:12]([O-])=O)[C:4](=[O:5])[O:3]1>O1CCCC1.[Pd]>[NH2:12][C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:11]=1[CH:2]([OH:1])[O:3][C:4]2=[O:5]

참가 물질

4

반응물 1

HCID 110955283-hydroxy-4-nitro-3H-isobenzofuran-1-one

생성물 1

HCID 151807284-Amino-3-hydroxyphthalide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

10 g of 3-hydroxy-4-nitro-phthalide are dissolved in 100 ml of tetrahydrofuran and hydrogenated at atmospheric pressure and at 20°-35° C. after adding 1 g of palladium on barium sulphate (5%). The catalyst is filtered off and the filtrate is concentrated. The evaporation residue is stirred with ether and filtered with suction. 5.8 g (68.5% of theory) of a colorless substance of melting point 280°-285° C. (dec.) are obtained.

후처리

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. filtrationfiltered with suction
  4. custom5.8 g (68.5% of theory) of a colorless substance of melting point 280°-285° C. (dec.) are obtained

출처 및 근거

ORD 기록
ord-b90a53a8f628485899bd02cf500cce53
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05100900

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