HCID 9980359, 화합물 → HCID 19370817, 화합물

HRID 2372849노트

반응식

HRID 2372849 반응식
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([OH:26])=[O:25])=[CH:14][CH:13]=2)[C:9](=[O:27])[C:8]([C:28]([O:30]CC)=[O:29])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]>FC(F)(F)C(O)=O>[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([OH:26])=[O:25])=[CH:16][CH:17]=2)[C:9](=[O:27])[C:8]([C:28]([OH:30])=[O:29])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 1

HCID 9980359HCID 9980359, 화합물

생성물 1

HCID 19370817HCID 19370817, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The title compound is prepared from 2-butyl-3-(2'-carboxybiphen-4-yl)methyl-5-ethoxycarbonylpyrimidin-4(3H)-one similarly to that in Example 9 by ester hydrolysis. The t-butyl ester is hydrolyzed in neat trifluoroacetic acid to give the title compound.

출처 및 근거

ORD 기록
ord-040cca0cb31a494db1370773befa1a3a
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05100897

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