참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | 4-Nitroanthranilic acid | HCID 12076 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 7-Nitroquinazolin-4(3H)-one | HCID 86222800 | 70.4% |
반응 단계
A mixture of 2-amino-4-nitrobenzoic acid (5.0 g, 27.5 mmol) and formamide (8.0 ml, 201.5 mmol) in a microwave reaction vessel was heated in a microwave reactor at 150° C. for 1 hr. The slurry was cooled to rt, stirred with aq. NaHCO3, filtered, washed with water followed by ether and dried in vacuum oven to provide 3.7 g of 7-nitroquinazolin-4(3H)-one (Compound 98-1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08642582B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_02 |
|---|
| ORD ID | ord-43df6153f9214497a90881c77e95dd32 |
|---|
| 출처 메모 | uspto-grants-2014_02 |
|---|
