Ammonia → 7-Nitroquinazolin-4-amine

HRID 237317

반응식

HRID 237317 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH3:15]>CO>[N+:12]([C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH2:15])=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1)([O-:14])=[O:13]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 8306804-Chloro-7-nitroquinazoline

생성물 1

HCID 136977987-Nitroquinazolin-4-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1.6 g of 4-chloro-7-nitroquinazoline in 50 ml 7N ammonia in methanol was stirred overnight at rt and concentrated to dryness. The solid was suspended in water, filtered, rinsed with water followed by ether and dried overnight in vacuum oven to provide 0.98 g of 7-nitroquinazolin-4-amine (Compound 98-2).

후처리

  1. concentrationconcentrated to dryness
  2. filtrationfiltered
  3. washrinsed with water
  4. customdried overnight in vacuum oven

출처 및 근거

ORD 기록
ord-9c94a77e0d38476da509652811c7b21c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642582B2

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