홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Acetic Acid → ethyl (2Z)-2-benzoyl-3-(5-methyl-3-pyridyl)acrylate

HRID 2373208
노트
인쇄 미리보기

반응식

HRID 2373208 반응식
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:9]=1)[CH:7]=O.[C:10]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.CC(O)=O.N1CCCCC1>CCO>[C:10](/[C:18](=[CH:7]/[C:6]1[CH:5]=[N:4][CH:3]=[C:2]([CH3:1])[CH:9]=1)/[C:19]([O:21][CH2:22][CH3:23])=[O:20])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 7170Ethyl benzoylacetateHCID 8082PiperidineHCID 141411585-Methylpyridine-3-carbaldehyde

생성물 1

HCID 86602398ethyl (2Z)-2-benzoyl-3-(5-methyl-3-pyridyl)acrylate수율 101.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5-methylnicotinaldehyde (400 mg), ethyl benzoylacetate (635 mg), AcOH (0.15 ml), piperidine (0.15 ml) in EtOH (5 ml) was stirred at room temperature for 24 hours. After evaporation, the residue was diluted with saturated aqueous NaHCO3 and extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo to give ethyl (2Z)-2-benzoyl-3-(5-methyl-3-pyridyl)acrylate (986 mg) as a yellow oil.

후처리

  1. customAfter evaporation
  2. additionthe residue was diluted with saturated aqueous NaHCO3
  3. extractionextracted with EtOAc
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-27d42d51e999429aac87dae60e9849ad
출처 데이터셋
uspto-grants-2008_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07459451B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트