8-chloro-4-dimethylaminomethylene-1-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → HCID 59851940, 화합물

HRID 2373367노트

반응식

HRID 2373367 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=O)[C:10](=[CH:13]N(C)C)[CH2:9][C:8](=[O:17])[N:7]([CH3:18])[C:6]=2[CH:19]=1.[NH:20]([C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=1)[C:21]([NH2:23])=[NH:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:22]=[C:21]([NH:20][C:24]4[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=4)[N:23]=[CH:13][C:10]=3[CH2:9][C:8](=[O:17])[N:7]([CH3:18])[C:6]=2[CH:19]=1

참가 물질

3

반응물 2

HCID 669346868-chloro-4-dimethylaminomethylene-1-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 178512548HCID 178512548, 화합물

생성물 1

HCID 59851940HCID 59851940, 화합물

실험 절차

In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-1-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-m) and 4-guanidinobenzoic acid were converted to I-7 (30%): HRMS Calcd. for C20H15ClN4O3: 395.0910, Found 395.0923.

출처 및 근거

ORD 기록
ord-f28af82618f646cf8f42f4ed00cc5cfd
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459448B2

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