HCID 66934668, 화합물 → 4-(10-Bromo-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)-benzoic acid

HRID 2373386노트

반응식

HRID 2373386 반응식
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[NH:6][C:7](=[O:16])[CH2:8][C:9](=[CH:12]N(C)C)[C:10](=O)[C:4]=2[CH:3]=1.[NH:19]([C:23]1[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=1)[C:20]([NH2:22])=[NH:21]>>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[NH:6][C:7](=[O:16])[CH2:8][C:9]3[CH:12]=[N:22][C:20]([NH:19][C:23]4[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=4)=[N:21][C:10]=3[C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 66934668HCID 66934668, 화합물HCID 178512548HCID 178512548, 화합물

생성물 1

HCID 598518434-(10-Bromo-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)-benzoic acid

실험 절차

In a manner similar to method I, 7-bromo-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-k) and 4-guanidinobenzoic acid were converted to I-25 (22%): HRMS Calcd. for C19H13BrN4O3: 425.0249, Found 425.0269.

출처 및 근거

ORD 기록
ord-1430d7897f7a40d3a115f477011d1e8f
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459448B2

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