Triacetoxyperiodinane → [3-(2-Oxo-1,3-oxazolidin-3-yl)phenyl]acetaldehyde

HRID 2373630노트

반응식

HRID 2373630 반응식
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C1=CC=CC=2)=O.[OH:23][CH2:24][CH2:25][C:26]1[CH:27]=[C:28]([N:32]2[CH2:36][CH2:35][O:34][C:33]2=[O:37])[CH:29]=[CH:30][CH:31]=1>ClCCl>[O:37]=[C:33]1[N:32]([C:28]2[CH:27]=[C:26]([CH2:25][CH:24]=[O:23])[CH:31]=[CH:30][CH:29]=2)[CH2:36][CH2:35][O:34]1

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 542438113-[3-(2-Hydroxyethyl)phenyl]-1,3-oxazolidin-2-one

생성물 1

HCID 57444342[3-(2-Oxo-1,3-oxazolidin-3-yl)phenyl]acetaldehyde수율 89%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1H)-one (Dess-Martin periodinane, 709 mg, 1.67 mmol) was added to a solution of 3-[3-(2-hydroxyethyl)phenyl]-1,3-oxazolidin-2-one (315 mg, 1.52 mmol) in dichloromethane (10 mL). The mixture was stirred at room temperature for 30 min, then washed with aqueous sodium hydroxide solution (1M, 10 mL). The separated organic layer the latter was dried over magnesium sulfate and concentrated under reduced pressure affording the title compound in 89% yield (278 mg). The compound was used without further purification in the next step.

후처리

  1. washwashed with aqueous sodium hydroxide solution (1M, 10 mL)
  2. dry with materialThe separated organic layer the latter was dried over magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b250ed121d9849f0a4947d482a56e3ff
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459456B2

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