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1,1'-Carbonyldiimidazole → (S)-hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one

HRID 2373663
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HRID 2373663 반응식
[NH2:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.[C:8](N1C=CN=C1)(N1C=CN=C1)=[O:9]>C(Cl)Cl>[CH2:2]1[NH:1][C:8](=[O:9])[N:4]2[CH2:5][CH2:6][CH2:7][C@@H:3]12
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참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 2734054(S)-(+)-2-(Aminomethyl)pyrrolidine

생성물 1

HCID 14358392(S)-hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(S)-2-(Aminomethyl)pyrrolidine (250 mg) and carbonyldiimidazole (400 mg, 1.0 equiv.) were dissolved in DCM (50 mL). The resulting mixture was stirred at room temperature for 18 hours, then concentrated under vacuum. The residue was purified by flash column chromatography (SPE cartridge, SiO2), using DCM-methanol (95:5) as eluent to afford the title compound as colourless solid (150 mg, 50% yield).

후처리

  1. concentrationconcentrated under vacuum
  2. customThe residue was purified by flash column chromatography (SPE cartridge, SiO2)

출처 및 근거

ORD 기록
ord-dffd5b37ef134704983f72fd548a7e20
출처 데이터셋
uspto-grants-2008_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07459456B2

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