Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Trifluoromethyl)phenylboronic acid → 3-Biphenyl-4-yl-2-(S)-[(5-chloro-2,4-dimethoxy-4'-trifluoromethyl-biphenyl-3-carbonyl)-amino]-propionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| 반응물 | 3-Bromo-5-chloro-2,6-dimethoxybenzoic acid | HCID 2800463 | — |
| 반응물 | (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate | HCID 15714801 | — |
| 생성물 | 3-Biphenyl-4-yl-2-(S)-[(5-chloro-2,4-dimethoxy-4'-trifluoromethyl-biphenyl-3-carbonyl)-amino]-propionic acid | HCID 59852610 | 61.6% |
반응 단계
2-(S)-amino-3-biphenyl-4-yl-propionic acid methyl ester (128 mg, 0.5 mmol) was reacted with 3-bromo-5-chloro-2,6-dimethoxybenzoic acid (148 mg, 0.5 mmol) as described in general procedure A. The resulting crude compound was reacted with 195 mg (1.0 mmol) of 4-(trifluoromethyl)phenylboronic acid as described in general procedure D. The product thus obtained was hydrolyzed according to general procedure C to afford the title product (180 mg) as a pure white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07459472B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-57a1e2897391479c81088f07a62eddf8 |
| 출처 메모 | uspto-grants-2008_12 |