Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl Peroxide → Methyl 5-(bromomethyl)pyrazine-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl Peroxide | HCID 7187 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 2-Pyrazinecarboxylic acid, 5-methyl-, methyl ester | HCID 465065 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Methyl 5-(bromomethyl)pyrazine-2-carboxylate | HCID 21973569 | 29.6% |
반응 단계
To a solution of 5-methyl-pyrazine-2-carboxylic acid methyl ester (2.0 g, 13.146 mmol) in CCl4 (25 mL0 was added NBS (2.57 g, 14.461 mmol) and benzoyl peroxide (0.318 g, 1.314 mmol) and the solution was heated at 70 C. for 1 h. Upon cooling to RT, the organic layer was washed with NaHCO3, water, dried (Na2SO4), and concentrated under reduced pressure to give 0.900 g 5-Bromomethyl-pyrazine-2-carboxylic acid methyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07459472B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-943813d9e5094dcda8d8d0ea79ce405a |
| 출처 메모 | uspto-grants-2008_12 |