Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-(Trifluoromethoxy)phenol | HCID 2733261 | — |
| 반응물 | Methyl 5-(bromomethyl)pyrazine-2-carboxylate | HCID 21973569 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester | HCID 69206346 | 88.1% |
반응 단계
A solution of 5-bromomethyl-pyrazine-2-carboxylic acid methyl ester (0.305 g, 1.314 mmol) in DMF (6 mL) was treated with 3-trifluoromethoxyphenol (0.280 g, 1.577 mmol) and potassium carbonate (0.400 g, 2.89 mmol) by the general procedure G. The crude product was purified by flash column chromatography on silica gel to give 0.380 g of pure 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester. LCMS: 330 (M+2)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07459472B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-b547a5d1b0354d98b065c0720cf92894 |
| 출처 메모 | uspto-grants-2008_12 |