HCID 11431851, 화합물 → HCID 11271536, 화합물

반응식

NC1C2N(C([C@H]3CC[C@H](C(O)=O)CC3)=NC=2C2C=CC=C(OCC3C=CC=CC=3)C=2)C=CN=1.C[O:35][C:36]([CH:38]1[CH2:43][CH2:42][CH:41]([C:44]2[N:48]3[CH:49]=[CH:50][N:51]=[C:52]([NH2:53])[C:47]3=[C:46]([C:54]3[CH:59]=[CH:58][CH:57]=[C:56]([O:60][CH2:61][C:62]4[C:67]([F:68])=[CH:66][CH:65]=[CH:64][C:63]=4[F:69])[CH:55]=3)[N:45]=2)[CH2:40][CH2:39]1)=[O:37]>>[NH2:53][C:52]1[C:47]2[N:48]([C:44]([CH:41]3[CH2:40][CH2:39][CH:38]([C:36]([OH:37])=[O:35])[CH2:43][CH2:42]3)=[N:45][C:46]=2[C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([O:60][CH2:61][C:62]3[C:63]([F:69])=[CH:64][CH:65]=[CH:66][C:67]=3[F:68])[CH:55]=2)[CH:49]=[CH:50][N:51]=1

참가 물질

반응물 2

HCID 11431851HCID 11431851, 화합물

HCID 178508471HCID 178508471, 화합물

생성물 1

HCID 11271536HCID 11271536, 화합물

실험 절차

The saponification procedures applied to the synthesis of trans-4-[8-Amino-1-(3-benzyloxy-phenyl)-imidazo[1,5-a]pyrazin-3-yl]-cyclohexanecarboxylic acid was applied to 4-{8-Amino-1-[3-(2,6-difluoro-benzyloxy)-phenyl]-imidazo[1,5-a]pyrazin-3-yl}-cyclohexanecarboxylic acid methyl ester to afford the title compound; MS (ES+): m/z 479.10 [MH+].

출처 및 근거

ORD 기록: ord-21a696554a2d49279f3688abfd8856c5
출처 데이터셋: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07459554B2

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