Potassium Carbonate → tert-Butyl 4-(2,6-dicarbamoylpyridin-4-yloxy)-3-fluorophenylcarbamate

HRID 2374039노트

반응식

HRID 2374039 반응식
[C:1]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([F:16])[CH:10]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].CC([O-])(C)C.[K+].Cl[C:24]1[CH:29]=[C:28]([C:30]([NH2:32])=[O:31])[N:27]=[C:26]([C:33]([NH2:35])=[O:34])[CH:25]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:30]([C:28]1[CH:29]=[C:24]([O:15][C:12]2[CH:13]=[CH:14][C:9]([NH:8][C:1](=[O:2])[O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[CH:10][C:11]=2[F:16])[CH:25]=[C:26]([C:33](=[O:34])[NH2:35])[N:27]=1)(=[O:31])[NH2:32]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 11708410tert-Butyl (3-Fluoro-4-hydroxyphenyl)carbamateHCID 199059102,6-Pyridinedicarboxamide, 4-chloro-HCID 23665647Potassium tert-butoxide

생성물 1

HCID 59852866tert-Butyl 4-(2,6-dicarbamoylpyridin-4-yloxy)-3-fluorophenylcarbamate수율 44%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of N-Boc-4-amino-2-fluorophenol (228 mg, 1.0 mmol) in DMF (2 mL) was treated with t-BuOK (124 mg, 1.1 mmol) and the mixture stirred at room temperature for 2 h. The mixture was treated with 4-chloropyridine-2,6-dicarboxamide (200 mg, 1.0 mmol) and K2CO3 (35 mg, 0.5 mmol) and heated at 80° C. for 1.5 h. The mixture was concentrated in vacuo, treated with EtOAc (10 mL) and H2O (10 mL) and filtered to remove the insoluble material. The EtOAc phase was washed with brine, dried (MgSO4) and concentrated in vacuo. Purification of the residue by flash column chromatography on SiO2 eluting with 30-100% EtOAc/hexanes gave the title compound (170 mg, 44%) as a white solid containing 10% of the starting chloropyridine. 1H NMR (DMSO-d6) δ 9.77 (s, 1H), 8.86 (s, 2H), 7.87 (s, 1H), 7.63 (d, 1H, J=12.1 Hz), 7.55 (s, 2H), 7.38-7.31 (m, 2H), 1.48 (s, 9H).

후처리

  1. temperatureheated at 80° C. for 1.5 h
  2. concentrationThe mixture was concentrated in vacuo
  3. additiontreated with EtOAc (10 mL) and H2O (10 mL)
  4. filtrationfiltered
  5. customto remove the insoluble material
  6. washThe EtOAc phase was washed with brine
  7. dry with materialdried (MgSO4)
  8. concentrationconcentrated in vacuo
  9. customPurification of the residue by flash column chromatography on SiO2 eluting with 30-100% EtOAc/hexanes

출처 및 근거

ORD 기록
ord-a058d3e8d1144d19a5a14818ce043f31
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459562B2

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