2-Bromopyridine → 1-(Pyridin-2-yl)-1H-pyrazole-4-carbaldehyde

HRID 2374142노트

반응식

HRID 2374142 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH:12]=[CH:11][C:10](C=O)=[N:9]1.[C:15](=O)([O-])[O-:16].[K+].[K+]>CN(C=O)C.O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:9]1[CH:10]=[C:11]([CH:15]=[O:16])[CH:12]=[N:8]1

참가 물질

6

반응물 3

HCID 79732-BromopyridineHCID 11430Potassium CarbonateHCID 122183831H-pyrazole-3-carbaldehyde

생성물 1

HCID 247048931-(Pyridin-2-yl)-1H-pyrazole-4-carbaldehyde

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

A mixture of 2-bromopyridine (3.4 mmol), 3-pyrazolecarboxaldehyde (3.2 mmol), and potassium carbonate (3.4 mmol) in anhydrous DMF (6 mL) was heated to 120° C. for 24 h. The reaction was cooled to RT, diluted with water, and extracted with EtOAc (3 x). The organic layers were combined and dried (Na2SO4), filtered, and concentrated. The title compound was obtained upon purification (SGC using EtOAc:hexanes gradient eluant from 0% to 100% EtOAc).

후처리

  1. temperatureThe reaction was cooled to RT
  2. extractionextracted with EtOAc (3 x)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ddf04c95c67f4704841a0f5dbde79a7b
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07462600B2

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