2-Fluoro-4-(piperazin-1-YL)benzonitrile → 2-Fluoro-4-[4-(5-methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-benzonitrile
반응식
[F:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([C:29]2[S:30][CH:31]=[CH:32][N:33]=2)=[C:24]([CH:28]=1)[C:25](O)=[O:26])(=[O:19])=[O:18]>>[F:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:11][CH2:12][N:13]([C:25](=[O:26])[C:24]3[CH:28]=[C:20]([S:17]([CH3:16])(=[O:19])=[O:18])[CH:21]=[CH:22][C:23]=3[C:29]3[S:30][CH:31]=[CH:32][N:33]=3)[CH2:14][CH2:15]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]참가 물질
3
실험 절차
The title compound was prepared according to the procedure E described for Example 9 from 2-Fluoro-4-piperazin-1-yl-benzonitrile [204192-45-0] and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 471.0 MH+.
출처 및 근거
- ORD 기록
- ord-0324013b263a4cb19645beb51e8cb6b2
- 출처 데이터셋
- uspto-grants-2008_12