Isopropanol → 7-Fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one

반응식

F[C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:13])[NH:5][CH:6]=[N:7]2.[CH:14]([OH:17])([CH3:16])[CH3:15]>>[F:12][C:10]1[CH:9]=[C:8]2[C:3]([C:4](=[O:13])[NH:5][CH:6]=[N:7]2)=[C:2]([O:17][CH:14]([CH3:16])[CH3:15])[CH:11]=1

참가 물질

반응물 2

HCID 3776Isopropanol

HCID 1355106875,7-Difluoro-3,4-dihydroquinazolin-4-one

생성물 1

HCID 1362314007-Fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one수율 73%

실험 절차

5,7-Difluoro-3,4-dihydroquinazolin-4-one was reacted with isopropanol to give 7-fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one in 73% yield; NMR Spectrum: (DMSOd6) 1.31 (s, 6H), 4.73 (m, 1H), 6.89 (m, 1H), 6.95 (m, 1H), 7.96 (s, 1H); Mass Spectrum: M+H+ 223.

출처 및 근거

ORD 기록: ord-f777f8ded35d4767b570927d1bae6996
출처 데이터셋: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07462623B2

반응 노트

불러오는 중…