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2,4-Dichloroaniline → N-(2,4-dichlorophenyl)-3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxamide

HRID 2374758
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HRID 2374758 반응식
ClC1C=C(Cl)C=CC=1CNC(C1C(=O)NN=C(C2C=CN=CC=2)C=1)=O.[O:26]=[C:27]1[C:32]([C:33]([OH:35])=O)=[CH:31][C:30]([C:36]2[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=2)=[N:29][NH:28]1.C(Cl)(=O)C(Cl)=O.[Cl:48][C:49]1[CH:55]=[C:54]([Cl:56])[CH:53]=[CH:52][C:50]=1[NH2:51]>C(N(CC)CC)C.CN(C)C=O.ClCCl>[Cl:48][C:49]1[CH:55]=[C:54]([Cl:56])[CH:53]=[CH:52][C:50]=1[NH:51][C:33]([C:32]1[C:27](=[O:26])[NH:28][N:29]=[C:30]([C:36]2[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=2)[CH:31]=1)=[O:35]
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참가 물질

8

반응물 4

HCID 111232,4-DichloroanilineHCID 65578Oxalyl chlorideHCID 10339420N-(2,4-dichlorobenzyl)-3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxamideHCID 127902383-Oxo-6-(pyridin-4-yl)-2,3-dihydropyridazine-4-carboxylic acid

생성물 1

HCID 10473713N-(2,4-dichlorophenyl)-3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxamide수율 199.4%

시약·촉매·용매 3

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

Working as in example 2 for the preparation of N-(2,4-dichlorobenzyl)-3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxamide, but starting with 0.3 g of 3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxylic acid, 10 cm3 of dichloromethane, 0.02 cm3 of dimethylformamide, 0.12 cm3 of oxalyl chloride, 0.036 g of 2,4-dichloroaniline and 0.19 cm3 of triethylamine, 0.16 g of N-(2,4-dichlorophenyl)-3-oxo-6-pyridin-4-yl-2,3-dihydropyridazine-4-carboxamide was obtained in the form of a cream-colored solid melting above 260° C.

출처 및 근거

ORD 기록
ord-a826de9c913d4330ba6d51326f1cf109
출처 데이터셋
uspto-grants-2008_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07462613B2

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