Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Methylthio)-1-propanol → (3-(3-Bromo-2-methylphenoxy)propyl)(methyl)sulfane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Methylthio)-1-propanol | HCID 10448 | — |
| 반응물 | Tributylphosphine | HCID 13831 | — |
| 반응물 | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| 반응물 | 3-Bromo-2-methylphenol | HCID 11171430 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (3-(3-Bromo-2-methylphenoxy)propyl)(methyl)sulfane | HCID 86697160 | — |
반응 단계
3-Bromo-2-methylphenol (0.10 g), 3-(methylthio)propanol (0.055 mL), tri-n-butyl phosphine (0.12 g) and 1,1′-(azodicarbonyl)dipiperidine (0.15 g) are stirred in tetrahydrofurane for 16 hours. Water is added and the mixture extracted with diethyl ether. The organic layer is washed with brine, dried (Na2SO4) and volatiles removed under reduced pressure. The product (80 mg) is obtained after column chromatography (silica gel, n-hexane/ethyl acetate gradient 100:0 to 50:50).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08642585B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-ef70e29ed21546b2a8527d437f2c62ee |
| 출처 메모 | uspto-grants-2014_02 |