Water → (S)-3-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propan-1-ol

HRID 237500노트

반응식

HRID 237500 반응식
Br[CH2:2][C@@H:3]([CH3:6])[CH2:4][OH:5].[Br:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([OH:15])=[CH:10][C:9]=1[CH3:16].C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Br:7][C:8]1[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH2:2][C@@H:3]([CH3:6])[CH2:4][OH:5])=[CH:10][C:9]=1[CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 819704-Bromo-3,5-dimethylphenolHCID 10986449(S)-(+)-3-Bromo-2-methyl-1-propanol

생성물 1

HCID 86697161(S)-3-(4-Bromo-3,5-dimethyl-phenoxy)-2-methyl-propan-1-ol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

(S)-3-Bromo-2-methyl-1-propanol (150 mg), 4-bromo-3,5-dimethylphenol (98.5 mg) and potassium carbonate are stirred in 5 mL of acetonitrile at 80° C. for 4 h. The reaction mixture is cooled to room temperature, water is added and the reaction mixture is extracted with diethyl ether. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give a solid, used in the next step without further purification. Yield: 130 mg.

후처리

  1. extractionthe reaction mixture is extracted with diethyl ether
  2. customThe organic phase is separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated under vacuum
  5. customto give a solid
  6. customused in the next step without further purification

출처 및 근거

ORD 기록
ord-f9e343ff26554e5aa368257b928847e3
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642585B2

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