Triethylamine → HCID 11453132, 화합물

HRID 2375016노트

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HRID 2375016 반응식
[CH3:1][C:2]1[N:3]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]2[C:10]=1[CH:9]=[N:8][C:7](SC)=[N:6]2.CC1N=C(C2C=CC=CC=2)N2C=1C=NC(S(C)(=O)=O)=N2.Cl.[N:40]1([CH2:46][CH2:47][O:48][C:49]2[CH:54]=[CH:53][C:52]([NH2:55])=[CH:51][CH:50]=2)[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1.C(N(CC)CC)C>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]2[C:10]=1[CH:9]=[N:8][C:7]([NH:55][C:52]1[CH:53]=[CH:54][C:49]([O:48][CH2:47][CH2:46][N:40]3[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]3)=[CH:50][CH:51]=1)=[N:6]2

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 45075259HCID 45075259, 화합물HCID 534718325-Methyl-2-(methylthio)-7-phenylimidazo[5,1-F][1,2,4]triazineHCID 534718335-Methyl-2-(methylsulfonyl)-7-phenylimidazo[5,1-F][1,2,4]triazine

생성물 1

HCID 11453132HCID 11453132, 화합물수율 8.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Applying the displacement procedure, using 5-methyl-2-(methylthio)-7-phenylimidazo[5,1-f][1,2,4]triazine (Intermediate 72) (50 mg, 0.17 mmol), (4-{[2-(1-piperidinyl)ethyl]oxy}phenyl)amine hydrochloride (45 mg, 0.17 mmol), triethylamine (0.024 mL, 0.17 mmol) and ethanol (2.5 mL) to afford 5-methyl-7-phenyl-N-(4-{[2-(1-piperidinyl)ethyl]oxy}phenyl)imidazo[5,1-f][1,2,4]triazin-2-amine (6 mg) as a yellow solid. MS m/z 429 (M+1).

출처 및 근거

ORD 기록
ord-66d8e0e1c86c4b18b325aae99f5ec414
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07462614B2

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