Oxalyl chloride → 1-(4-Methoxyphenyl)cyclohexanecarbonyl chloride

HRID 2375211

반응식

HRID 2375211 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:15]([OH:17])=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:21])=O>ClCCl.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:15]([Cl:21])=[O:17])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 819791-(4-Methoxyphenyl)cyclohexanecarboxylic acid

생성물 1

HCID 27596461-(4-Methoxyphenyl)cyclohexanecarbonyl chloride수율 101.4%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

To a solution of 1-(4-methoxyphenyl)-cyclohexanecarboxylic acid (E3) (0.075 g, 0.32 mmol) in dry dichloromethane (2 ml) under argon atmosphere at ice bath temperature oxalyl chloride (0.327 g, 2.57 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at room temperature for 15 minutes and at 40° C. for one hour, then concentrated under reduced pressure to give crude title product (0.082 g, ca. 100%). The crude product was immediately utilized in the next step of the synthesis without further purification.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-66b309671c7549f5af54fa082938deee
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07465719B2

연결된 노트

불러오는 중…