Oxalyl chloride → 1-Phenylcyclohexanecarbonyl chloride

HRID 2375212노트

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HRID 2375212 반응식
[C:1]1([C:7]2([C:13]([OH:15])=O)[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C)C=O>[C:1]1([C:7]2([C:13]([Cl:19])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 708171-Phenylcyclohexane-1-carboxylic acid

생성물 1

HCID 103535371-Phenylcyclohexanecarbonyl chloride수율 102.5%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

To a solution of 1-phenylcyclohexanecarboxylic acid (E7) (0.095 g, 0.46 mmol) in dry dichloromethane (3 ml) under argon atmosphere at ice bath temperature oxalyl chloride (0.468 g, 3.68 mmol) and one drop of dimethylformamide were added. The reaction mixture was stirred at room temperature for 15 minutes and at 40° C. for one hour, then concentrated under reduced pressure to give crude title compound (0.105 g, ca. 100%). The crude product was immediately utilized in the next step of the synthesis without further purification.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9d333f9e30da4621922410ab2cc86c84
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07465719B2

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