참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluidine | HCID 7813 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 6-Chloro-n4-(4-methylphenyl)pyrimidine-2,4-diamine | HCID 238748 | 85.2% |
반응 단계
A mixture of 4,6-dichloro-2-pyrimidinamine (1.64 g, 0.01 mol), p-toluidine (1.07 g, 0.01 mol) in dioxane (2 mL) was heated in a sealed tube for 30 minutes at 140° C. The crude product was treated with NaOH (50 ml, 2M) and extracted with CH2Cl2 (3×50 mL). The organic layer was washed with brine (2×100 mL), dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified by chromatography on silica using hexane/EtOAc (1:3), giving the desired product (2 g, 78%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07465750B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_12 |
|---|
| ORD ID | ord-5c1dee1e6e954695b9d24eb6a59d79da |
|---|
| 출처 메모 | uspto-grants-2008_12 |
|---|
