4-Amino-5-iodo-2-(trifluoromethyl)benzonitrile → 4-Amino-5-cyano-2-trifluoromethyl-benzonitrile
반응식
[NH2:1][C:2]1[C:9](I)=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.[C:15]([Cu])#[N:16]>CN1C(=O)CCC1>[NH2:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:13])[F:12])[C:5]([C:6]#[N:7])=[CH:8][C:9]=1[C:15]#[N:16]참가 물질
4
실험 절차
4-Amino-5-iodo-2-trifluoromethyl-benzonitrile (1.5 mmoL), CuCN (1.7 mmoL) in NMP (10 mL) was heated at 150° C. for 4 hrs. The reaction mixture was passed through a pad of Celite. The reaction mixture was then partitioned between ethyl acetate and water. The organic layer was washed with water, then brine, dried over anhydrous Na2SO4, filtered and concentrated to yield the title compound as a brown solid.
후처리
- customThe reaction mixture was then partitioned between ethyl acetate and water
- washThe organic layer was washed with water
- dry with materialbrine, dried over anhydrous Na2SO4
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-fb60a897a6e749d681644c3028839bab
- 출처 데이터셋
- uspto-grants-2008_12
- 특허 번호
- US07465809B2
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