HCID 69277653, 화합물 → HCID 69275634, 화합물

HRID 2375823노트

반응식

HRID 2375823 반응식
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][O:17][CH3:18])[C:11](=[O:19])[CH:10]=1)C1C=CC=CC=1>[Pd].C(OCC)(=O)C>[OH:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][O:17][CH3:18])[C:11](=[O:19])[CH:10]=1

참가 물질

4

반응물 1

HCID 69277653HCID 69277653, 화합물

생성물 1

HCID 69275634HCID 69275634, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 4-benzyloxy-1-(2-methoxy-ethyl)-1H-pyridin-2-one (1.4 g) and 10% palladium on carbon (100 mg) was stirred in ethyl acetate (50 mL) under a hydrogen atmosphere for 17 h. Then, the mixture was filtered through celite and concentrated to afford 4-hydroxy-1-(2-methoxy-ethyl)-1H-pyridin-2-one as a colourless solid. δH (300 MHz, CH3OD) 3.67 (2H, t), 4.10 (2H, t), 4.86 (3H, s), 5.85 (1H, d), 6.04 (1H, dd) and 7.48 (1H, d).

후처리

  1. filtrationThen, the mixture was filtered through celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e655f7b66ae24999bb7d944c707981ef
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07465726B2

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