HCID 68967238, 화합물 → 2-(pyrrolidin-1-ylmethyl)aniline

HRID 2376163노트

반응식

HRID 2376163 반응식
C([CH:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-])=O)C>[Pd].CO>[N:4]1([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH2:5][CH2:6][CH2:7][CH2:3]1

참가 물질

4

반응물 1

HCID 68967238HCID 68967238, 화합물

생성물 1

HCID 2643112-(pyrrolidin-1-ylmethyl)aniline수율 115.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of ethyl 1-(2-nitrobenzyl)pyrrolidine (1.90 g) and 10% palladium on carbon (200 mg) in methanol (40 mL) was hydrogenated at ambient temperature. After completion of the reaction, the catalyst in the reaction mixture was removed by filtration. The solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform/methanol=20/1 v/v) to give [2-(1-pyrrolidinylmethyl)phenyl]amine (1.65 g) as a pale yellow solid.

후처리

  1. customwas hydrogenated at ambient temperature
  2. customAfter completion of the reaction
  3. customthe catalyst in the reaction mixture was removed by filtration
  4. customThe solvent was evaporated in vacuo
  5. customThe residue was purified by silica gel column chromatography (chloroform/methanol=20/1 v/v)

출처 및 근거

ORD 기록
ord-af209a647af441289dcc1e5da739eb1a
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07465731B2

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