Ethanol hydrochloride → (2Z)-3-(5-chloro-6-{[(3R)-1-cyclopentyl-3-pyrrolidinyl]amino}-3-pyridinyl)-2-fluoro-N-hydroxyacrylamide dihydrochloride

HRID 2376194노트

반응식

HRID 2376194 반응식
[ClH:1].CCO.[Cl:5][C:6]1[CH:7]=[C:8](/[CH:23]=[C:24](\[F:35])/[C:25]([NH:27][O:28]C2CCCCO2)=[O:26])[CH:9]=[N:10][C:11]=1[NH:12][C@@H:13]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH2:14]1>CCO>[ClH:5].[ClH:1].[Cl:5][C:6]1[CH:7]=[C:8](/[CH:23]=[C:24](\[F:35])/[C:25]([NH:27][OH:28])=[O:26])[CH:9]=[N:10][C:11]=1[NH:12][C@@H:13]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22]2)[CH2:14]1

참가 물질

4

반응물 2

HCID 21887872Ethanol hydrochlorideHCID 86603746(2Z)-3-(5-chloro-6-{[(3R)-1-cyclopentyl-3-pyrrolidinyl]amino}-3-pyridinyl)-2-fluoro-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide

생성물 1

HCID 86603834(2Z)-3-(5-chloro-6-{[(3R)-1-cyclopentyl-3-pyrrolidinyl]amino}-3-pyridinyl)-2-fluoro-N-hydroxyacrylamide dihydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
22.5 °C

실험 절차

A solution of 2N HCl-EtOH solution (3.4 ml) was added to a mixture of (2Z)-3-(5-chloro-6-{[(3R)-1-cyclopentyl-3-pyrrolidinyl]amino}-3-pyridinyl)-2-fluoro-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (620 mg) in EtOH (5 ml) and stirred at 20-25° C. for 2 hours. IPE (20 ml) was added to a reaction mixture and the resultant mixture was stirred at ambient temperature for 20 minutes. The precipitate was collected by filtration to give (2Z)-3-(5-chloro-6-{[(3R)-1-cyclopentyl-3-pyrrolidinyl]amino}-3-pyridinyl)-2-fluoro-N-hydroxyacrylamide dihydrochloride (500 mg).

후처리

  1. additionIPE (20 ml) was added to a reaction mixture
  2. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-97f9c17255c340d2906be9bd0b4f48e5
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07465731B2

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