4-Bromo-2,6-dimethylpyrimidine → 4-(4-Bromo-3,5-dimethyl-phenyl)-2,6-dimethyl-pyrimidine

반응식

[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Br[C:20]1[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([CH3:27])[N:21]=1>>[Br:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([CH3:27])[N:21]=2)=[CH:6][C:7]=1[CH3:8]

참가 물질

반응물 2

HCID 109652454-Bromo-2,6-dimethylpyrimidine

HCID 569731362-(4-Bromo-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

생성물 1

HCID 866973074-(4-Bromo-3,5-dimethyl-phenyl)-2,6-dimethyl-pyrimidine

실험 절차

The title compound is prepared from 2-bromo-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 4-bromo-2,6-dimethyl-pyrimidine following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 7): tR=1.01 min; Mass spectrum (ESI+): m/z=291/293 (Br) [M+H]+.

출처 및 근거

ORD 기록: ord-c77bf69497f8481e8bc26f3ce54c1ded
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08642585B2

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