4-Isobutyl-3-nitro quinoline → 4-Isobutyl 3-amino quinoline

HRID 23766

반응식

HRID 23766 반응식
[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[N+:15]([O-])=O)[CH:2]([CH3:4])[CH3:3]>C1(C)C=CC=CC=1.[Pd]>[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[CH:7][C:6]=1[NH2:15])[CH:2]([CH3:4])[CH3:3]

참가 물질

4

반응물 1

HCID 225904984-Isobutyl-3-nitro quinoline

생성물 1

HCID 225904974-Isobutyl 3-amino quinoline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 1140Toluene용매

실험 절차

The nitroxide group on the 4-isobutyl-3-nitro quinoline produced in Example 1 is reduced by catalytic reduction using toluene as solvent, Pd/C 5% (50% wet) as catalyst, at 40-45° C. and atmospheric pressure to produce 4-isobutyl 3-amino quinoline. The rate of reaction depends on efficiency of stirring. After catalyst filtration the solution is ready for the next step.

출처 및 근거

ORD 기록
ord-7ccd7f7189f341b1b43a770b427734af
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852861B2

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