Morpholine → HCID 58855409, 화합물

HRID 2376605노트

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HRID 2376605 반응식
[F:1][C:2]([F:18])([C:9]([F:17])([F:16])[C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])[CH2:3][O:4][CH2:5][CH:6]1[O:8][CH2:7]1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[O:22]1[CH2:23][CH2:24][N:19]([CH2:7][CH:6]([OH:8])[CH2:5][O:4][CH2:3][C:2]([F:18])([F:1])[C:9]([F:17])([F:16])[C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])[CH2:20][CH2:21]1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 27758863-(1h,1h,5h-Octafluoropentyloxy)-1,2-epoxypropane

생성물 1

HCID 58855409HCID 58855409, 화합물수율 89.1%

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온도
80 °C

실험 절차

28.8 g of glycidyl 2,2,3,3,4,4,5,5-octafluoropentyl ether was added dropwise to 8.7 g of morpholine. The mixture was then stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography. There was obtained 33.4 g of 1-morpholino-3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-2-propanol (yield 89%).

후처리

  1. customThe reaction mixture was directly purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-2486bcc7ee5744469b72e13b206d08ae
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07468236B2

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