Sulfanilamide → 4-[4-[4,6-Bis(4-fluorophenyl)-2-methylpyrazolo[3,4-b]pyridin-5-yl]pyridin-2-ylamino]benzenesulfonamide

HRID 2376768노트

반응식

Cl[C:2]1[CH:7]=[C:6]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[N:12][C:11]3=[N:21][N:22]([CH3:24])[CH:23]=[C:10]3[C:9]=2[C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)[CH:5]=[CH:4][N:3]=1.[NH2:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([NH2:42])(=[O:41])=[O:40])=[CH:35][CH:34]=1>>[F:31][C:28]1[CH:29]=[CH:30][C:25]([C:9]2[C:10]3[C:11](=[N:21][N:22]([CH3:24])[CH:23]=3)[N:12]=[C:13]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[C:8]=2[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:32][C:33]3[CH:38]=[CH:37][C:36]([S:39]([NH2:42])(=[O:40])=[O:41])=[CH:35][CH:34]=3)[CH:7]=2)=[CH:26][CH:27]=1

참가 물질

반응물 2

HCID 5333Sulfanilamide

HCID 86606799HCID 86606799, 화합물

생성물 1

HCID 670149714-[4-[4,6-Bis(4-fluorophenyl)-2-methylpyrazolo[3,4-b]pyridin-5-yl]pyridin-2-ylamino]benzenesulfonamide수율 17.6%

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온도: 190 °C

실험 절차

A mixture of 5-(2-chloropyridin-4-yl)-4,6-bis(4-fluorophenyl)-2-methylpyrazolo[3,4-b]pyridine (100 mg, 0.23 mmol, obtained in example 190) and 4-aminobenzenesulfonamide (46 mg, 0.27 mmol) was heated at 190° C. overnight. It was allowed to cool and the crude product obtained was purified by chromatography on silica gel using EtOAc as eluent, to afford 23 mg of the desired compound (yield: 17%).

후처리

temperatureto cool
customthe crude product obtained
customwas purified by chromatography on silica gel

출처 및 근거

ORD 기록: ord-45abfbd8c84e460d90ea54221b137f58
출처 데이터셋: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07468376B2

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