Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-bromobenzoate → Methyl 2-[(4-bromophenyl)sulfonyl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-bromobenzoate | HCID 11894 | — |
| 반응물 | Sodium 4-bromobenzene-1-sulfinate--water (1/1/2) | HCID 23683129 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Methyl 2-[(4-bromophenyl)sulfonyl]benzoate | HCID 21099525 | — |
반응 단계
Methyl 2-[(4-bromophenyl)sulfonyl]benzoate was prepared according to the method of Example 135, Step 2 using methyl 2-bromobenzoate (2.8 mL, 20 mmol) in place of (S)-1-(2-iodophenyl)ethanol and sodium 4-bromophenylsulfinate dihydrate (5.6 g, 20 mmol) in place of Intermediate 1, together with CuI (19 g, 100 mmol) and DMSO (40 mL), affording product as a white solid (3.8 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07468393B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-b78c719f709948d286aa5bc8f3621bc0 |
| 출처 메모 | uspto-grants-2008_12 |