gamma-Cyhalothrin → (1RS)-cis-3-(Z-2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride

HRID 2377124

반응식

HRID 2377124 반응식
[CH3:1][C:2]1([CH3:31])[C@H:4]([C:5](O[C@@H](C2C=CC=C(OC3C=CC=CC=3)C=2)C#N)=[O:6])[C@@H:3]1/[CH:24]=[C:25](\[Cl:30])/[C:26]([F:29])([F:28])[F:27].[Cl:32]/C(/C(F)(F)F)=C\[C@@H]1[C@H](C(O)=O)C1(C)C>>[Cl:30]/[C:25](/[C:26]([F:29])([F:28])[F:27])=[CH:24]\[C@@H:3]1[C@H:4]([C:5]([Cl:32])=[O:6])[C:2]1([CH3:31])[CH3:1]

참가 물질

3

반응물 2

HCID 6440554gamma-CyhalothrinHCID 11184106(1S-cis)-Cyhalothric acid

생성물 1

HCID 11334477(1RS)-cis-3-(Z-2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride

실험 절차

There is therefore provided a process for the preparation of gamma-cyhalothrin comprising a) chlorinating 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid (V) to give 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride (III); b) esterifying 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride (III) with 3-phenoxy benzaldehyde (IV) in the presence of a source of cyanide to form a diastereoisomeric mixture of 1R cyhalothrin isomers (II) and c) epimerising the diastereoisomeric mixture (II) under conditions in which the least soluble diastereoisomer (I) crystallises from solution.

후처리

  1. customThere is therefore provided a process

출처 및 근거

ORD 기록
ord-2ab09f6ef2cc4478b00bcda7502ad4b2
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07468453B2

연결된 노트

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