4-Fluoro-2-hydroxyphenacyl bromide → 6-Fluoro-2,3-dihydro-1-benzofuran-3-one
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[OH:12])=[O:4]>CN(C=O)C.O>[F:11][C:8]1[CH:9]=[CH:10][C:5]2[C:3](=[O:4])[CH2:2][O:12][C:6]=2[CH:7]=1참가 물질
4
실험 절차
CsCO3 (5.36 g) was added in portions over 10 min to an ice cold solution of Example 1109A (3.2 g) in DMF (140 mL). The resulting mixture was stirred for 30 min then diluted with water and extracted with ether (3×). the combined extracts were dried (Na2SO4), and concentrated to give 1.6 g of the title compound. MS ESI(−) m/e 151.1 (M−H)−.
후처리
- extractionextracted with ether (3×)
- dry with materialthe combined extracts were dried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-5017a460639f48b887a99440acc67f77
- 출처 데이터셋
- uspto-grants-2008_12
- 특허 번호
- US07468371B2
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