2-Methylaziridine → 2-Methyl-1-Tosyl-Aziridine

HRID 23775

반응식

HRID 23775 반응식
[CH3:1][CH:2]1[CH2:4][NH:3]1.[C:5]1([CH3:15])[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1>[OH-].[K+]>[CH3:1][CH:2]1[CH2:4][N:3]1[S:11]([C:8]1[CH:9]=[CH:10][C:5]([CH3:15])=[CH:6][CH:7]=1)(=[O:13])=[O:12]

참가 물질

4

반응물 2

HCID 63772-MethylaziridineHCID 73974-Toluenesulfonyl chloride

생성물 1

HCID 5448752-Methyl-1-Tosyl-Aziridine수율 58.5%

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

반응 조건

온도
0 °C

실험 절차

2-Methylaziridine (3.6 ml, 51 mmol) was added to a 10% aqueous KOH solution (30 ml) and cooled in an ice bath for 30 min. To this solution p-toluenesulfonyl chloride (9.9 g, 52 mmol) was added rapidly while maintaining the temperature below 4° C. The resulting mixture was stirred for 30 min at 0° C., then stirred at room temperature overnight. The white precipitate was washed multiple times with cold water and dried under vacuum. The washed product was dissolved in hot petroleum ether and allowed to crystallize at 0° C., yielding colorless crystals (6.3 g, 57% yield).

후처리

  1. temperaturecooled in an ice bath for 30 min
  2. temperaturewhile maintaining the temperature below 4° C
  3. stirringstirred at room temperature overnight
  4. washThe white precipitate was washed multiple times with cold water
  5. customdried under vacuum
  6. dissolutionThe washed product was dissolved in hot petroleum ether
  7. customto crystallize at 0° C.

출처 및 근거

ORD 기록
ord-cf0ac7519533440aacba03633ef402c8
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852865B2

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