Isopropylamine → Isopropylpent-4-enylamine

반응식

Br[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[CH:7]([NH2:10])([CH3:9])[CH3:8]>>[CH:7]([NH:10][CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6])([CH3:9])[CH3:8]

참가 물질

반응물 2

HCID 6363Isopropylamine

HCID 707041-Pentene, 5-bromo-

생성물 1

HCID 551578Isopropylpent-4-enylamine수율 40%

반응 조건

온도: 60 °C

실험 절차

5-Bromo-1-pentene (42.3 mmol) was added to isopropylamine (423 mmol), and the mixture was stirred at 60° C. for 48 h in the dark in a sealed tube. Then the volatiles were evaporated at reduced pressure and the crude residue was dissloved in 50 mL of diethyl ether and washed twice with water. The organic phase was dried over Na2SO4. Evaporation of the solvent gave N-isopropylpent-4-en-1-amine as brownish oil (40%) which was used without any further purification.

후처리

customThen the volatiles were evaporated at reduced pressure
washwashed twice with water
dry with materialThe organic phase was dried over Na2SO4
customEvaporation of the solvent

출처 및 근거

ORD 기록: ord-a99b8692e57248e7be131da6ec9e231f
출처 데이터셋: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07470664B2

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