Morpholine → HCID 178494188, 화합물

반응식

[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]1[NH:11][C:12]([C:16]([OH:18])=O)=[C:13]([CH3:15])[N:14]=1.C(N(CC)CC)C.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1.C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F>>[I:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8][CH3:9])[C:3]=1[C:10]1[NH:11][C:12]([C:16]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[O:18])=[C:13]([CH3:15])[N:14]=1

참가 물질

반응물 4

HCID 8083Morpholine

HCID 8471Triethylamine

HCID 2724699PyBOP

HCID 178494191HCID 178494191, 화합물

생성물 1

HCID 178494188HCID 178494188, 화합물수율 52%

실험 절차

To a stirred solution of 2-(4-iodo-2-methoxypyridin-3-yl)-4-methyl-1H-imidazole-5-carboxylic acid (0.039 g, 0.1085 mmol) in N,N-diemthylformamide (2 mL) was added triethylamine (60 mL, 0.434 mmol), morpholine (14 mL, 0.1627 mmol) and PyBOP (85 mgs, 0.1627 mmol) at room temperature. The reaction was stirred at room temperature for 10 minutes then the solvent was evaporated. The residue was dissolved in ethyl acetate and washed with water and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified on Prep HPLC (ammonium acetate/acetonitrile/water) to give the title material (0.024 g, 52%). 1H NMR (400 MHz, DMSO-d6) δ (ppm): 2.32 (s, 3H) 3.54 (s, 8H) 3.76 (s, 3H) 7.55 (d, J=5.31 Hz, 1H) 7.87 (d, J=5.31 Hz, 1H).