1-Benzyloxy-4-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-benzene → 4-(3,3,5,5-Tetramethyl-cyclohexyl)-phenol

HRID 237811노트

반응식

HRID 237811 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH2:20][C:19]([CH3:22])([CH3:21])[CH2:18][C:17]([CH3:24])([CH3:23])[CH:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.CCOC(C)=O.[Pd]>[CH3:23][C:17]1([CH3:24])[CH2:18][C:19]([CH3:21])([CH3:22])[CH2:20][CH:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)[CH2:16]1

참가 물질

5

반응물 1

HCID 685258151-Benzyloxy-4-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-benzene

생성물 1

HCID 685258634-(3,3,5,5-Tetramethyl-cyclohexyl)-phenol수율 96.6%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To 10% Pd/C (0.17 g) under N2 was added 1-benzyloxy-4-(3,3,5,5-tetramethyl-cyclohex-1-enyl)-benzene (1.7 g, 5.3 mmol), prepared by a substantially similar procedure to that of Step 1 of Example 18, in MeOH (15 mL) and EtOAc (15 mL). This mixture was stirred under H2 (1 atm) overnight. The reaction mixture was filtered through celite. The filtrate was concentrated to give the title compound as a white solid (1.19 g).

후처리

  1. customprepared by a substantially similar procedure to that of Step 1 of Example 18
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-8b5b782ad61043aab7f5d69373edc6f7
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642603B2

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