HCID 69205838, 화합물 → HCID 69204178, 화합물

HRID 2378275노트

반응식

HRID 2378275 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)[OH:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)[CH:15]=2)=[O:13])[CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH3:2]

참가 물질

4

반응물 1

HCID 69205838HCID 69205838, 화합물

생성물 1

HCID 69204178HCID 69204178, 화합물

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매2회HCID 6344Dichloromethane용매

실험 절차

A mixture of (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl) -methanol from above and activated MnO2 (2.6 g, 30 mmol) in methylene chloride (30 if L) was stirred at room temperature for 18 h. More MnO2 (2 g) was added and kept for overnight. The suspension was filtered thru a pad of Celite. Removal of solvent gave (3-ethoxy-4-methoxy-phenyl)-(3-pyrrol-1-yl-phenyl)-methanone as a brown oil (1.58 g, 85% crude yield 2 steps). The sample was used in the next step without further purification.

후처리

  1. waitkept for overnight
  2. filtrationThe suspension was filtered
  3. customRemoval of solvent

출처 및 근거

ORD 기록
ord-67d17ecd437d444ea959d2de81fb4211
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470723B2

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