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HCID 11013136, 화합물 → (S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-hexan-1-ol

HRID 2378491
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HRID 2378491 반응식
C([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([CH3:23])[CH2:14][O:15][Si:16]([C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:18])[CH3:17])C1C=CC=CC=1>C1COCC1.[OH-].[OH-].[Pd+2]>[C:19]([Si:16]([CH3:18])([CH3:17])[O:15][CH2:14][C@@H:13]([CH3:23])[CH2:12][CH2:11][CH2:10][CH2:9][OH:8])([CH3:21])([CH3:22])[CH3:20]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 11013136HCID 11013136, 화합물

생성물 1

HCID 10933803(S)-6-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-hexan-1-ol수율 100.2%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 64.0 g (0.19 mol) of the benzylether VIII in 500 ml of THF was hydrogenated (3.5 bar) over 7.0 g of 20% Pd(OH)2/C for 30 min at ambient temperature. The catalyst was removed by filtration and the filtrate was concentrated to afford alcohol IX as colorless oil (46.9 g, 100%). Rf=0.33 (SiO2, 1:1 heptane-TBME).

후처리

  1. customfor 30 min
  2. customat ambient temperature
  3. customThe catalyst was removed by filtration
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-eb8685b4b890481db2689f40765bc50c
출처 데이터셋
uspto-grants-2008_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07470792B2

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