Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate → HCID 22558762, 화합물

HRID 2378530노트

반응식

HRID 2378530 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]>C(OCC)(=O)C.CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

5

반응물 1

HCID 53705486Ethyl 3-(3-fluoro-4-methyloxyphenyl)Acrylate

생성물 1

HCID 22558762HCID 22558762, 화합물수율 99.4%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of Intermediate 7 (3.01 g) in ethyl acetate (50 ml) and methanol (25 ml) was added with 10% palladium/carbon (300 mg, Merck), and stirred at room temperature for 2 hours under hydrogen atmosphere. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to obtain the title compound (Intermediate 8, 3.02 g).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent of the filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3cec7341f3274df9a0847e009ebb01c9
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470807B2

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